Bez from the Happy Mondays has nothing to do with this article.
 
Why would someone do this to themselves? I mean, no wonder! How the hell did this guy expect he’d end up after taking 40,000 E’s?

Doctors from London University have revealed details of what they believe is the largest amount of ecstasy ever consumed by a single person. Consultants from the addiction centre at St George’s Medical School, London, have published a case report of a British man estimated to have taken around 40,000 pills of MDMA, the active ingredient in ecstasy, over nine years. The heaviest previous lifetime intake on record is 2,000 pills. Though the man, who is now 37, stopped taking the drug seven years ago, he still suffers from severe physical and mental health side-effects, including extreme memory problems, paranoia, hallucinations and depression. He also suffers from painful muscle rigidity around his neck and jaw which often prevents him from opening his mouth. The doctors believe many of these symptoms may be permanent.

The man, known as Mr A in the report in the scientific journal Psychosomatics, started using ecstasy at 21. For the first two years his use was an average of five pills per weekend. Gradually this escalated until he was taking around three and a half pills a day. At the peak, the man was taking an estimated 25 pills every day for four years. After several severe collapses at parties, Mr A decided to stop taking ecstasy. For several months, he still felt he was under the influence of the drug, despite being bedridden.

His condition deteriorated and he began to experience recurrent tunnel vision and other problems including hallucinations, paranoia and muscle rigidity. “He came to us after deciding that he couldn’t go on any more,” said Dr Christos Kouimtsidis, the consultant psychiatrist at St George’s Medical School in Tooting who treated him for five months. “He was having trouble functioning in everyday life.”

The doctors discovered that the man was suffering from severe short-term memory problems of a type usually only seen in lifetime alcoholics. But evaluating the full extent of his condition was difficult as his concentration and attention was so impaired he was unable to follow the simple tasks involved in the test.

“This was an exceptional case. His long- term memory was fine but he could not remember day to day things - the time, the day, what was in his supermarket trolley,” said Dr Kouimtsidis. “More worryingly, he did not seem aware himself that he had these memory problems.”
 
Below, Pulp’s Jarvis Cocker sings his wryly observed outsider’s tale of being on E at a rave and not quite getting it, Sorted for E’s and Wizz:
 

 
The strange case of the man who took 40,000 ecstasy pills in nine years